Polynucleotides vs Profhilo : The New Generation of Skin Boosters
- Nicole O'Grady
- Jun 2
- 5 min read
Updated: 17 hours ago
If you’ve been researching treatments to improve skin quality, you’ve probably come across both Profhilo and Polynucleotides.
They are two of the most talked about treatments in modern aesthetics, and for good reason. Both can improve skin texture, elasticity, and overall skin health without changing your facial features.
However, despite often being mentioned together, they are not the same treatment and they don’t deliver the same results. Understanding how each works can help you make an informed decision about which treatment is most suitable for your skin concerns and aesthetic goals.
At Olivia Cole, we take the time to assess your skin, discuss your concerns, and recommend the most suitable treatment plan.
Polynucleotides vs Profhilo - which one is better for me?
The truth is, both treatments are excellent. However, they work in very different ways and are designed for different skin concerns.
Profhilo is often described as a skin booster, but it’s actually a bio-remodelling treatment made from one of the highest concentrations of pure hyaluronic acid available.
Rather than adding volume like filler, Profhilo spreads beneath the skin to deeply hydrate and stimulate collagen and elastin production.
The results are:
Improved skin hydration
Better skin texture
Increased radiance and glow
Mild skin tightening
Smoother fine lines
Many patients describe Profhilo as giving their skin a healthier, fresher appearance without looking like they’ve had any work done.
It’s particularly popular for:
Dull or dehydrated skin
Early signs of ageing
Crepey skin on the face, neck, chest, or hands
Patients wanting preventative treatments
Polynucleotides are one of the most exciting regenerative treatments currently available in aesthetics.
Rather than focusing primarily on hydration, they work by stimulating tissue repair and encouraging the skin to regenerate itself.
Polynucleotides help improve:
Skin quality and resilience
Collagen production
Elasticity
Inflammation
Skin healing and repair
Think of them as a treatment that focuses on rebuilding and strengthening the skin from within.
They are particularly effective for:
Thin or fragile skin
Under-eye concerns
Loss of elasticity
Acne scarring
Sun-damaged skin
Mature skin showing signs of ageing
What’s the Main Difference?
Profhilo hydrates and remodels.
Polynucleotides regenerate and repair.
While both stimulate collagen production, Profhilo is often chosen when skin appears tired, dull, or dehydrated. Polynucleotides are typically recommended when the focus is on skin health, tissue quality, healing, and long-term regeneration.
Which Treatment Gives Better Results?
Neither treatment is universally “better.” The best choice depends entirely on your skin concerns, age, skin quality, and treatment goals.
Profhilo may be more suitable if you:
Want improved glow and hydration
Notice crepey or dehydrated skin
Are looking for a preventative anti-ageing treatment
Prefer a simple treatment protocol
Polynucleotides may be more suitable if you:
Have thinning or fragile skin
Are concerned about under-eye ageing
Want to improve skin quality and elasticity
Have acne scarring or damaged skin
Are looking for a regenerative approach
During a consultation at Olivia Cole we assess your skin and create a personalised treatment plan based on what will actually benefit you rather than simply following trends.
Can You Have Both?
Absolutely. In fact, combining treatments is becoming increasingly popular because they target different aspects of skin ageing.
Many patients begin with a course of Polynucleotides to improve skin health and regeneration before introducing Profhilo to enhance hydration, glow, and overall skin quality. When used strategically, the treatments can complement each other extremely well.
What Areas Can Be Treated?
Profhilo
Common treatment areas include:
Face
Neck
Décolletage
Hands
Polynucleotides
Common treatment areas include:
Under eyes
Face
Neck
Décolletage
Hands
Polynucleotides are particularly popular for delicate under-eye skin where traditional filler may not always be appropriate.
How Many Treatments Are Needed?
Profhilo is usually performed as:
Two treatments
Four weeks apart
Maintenance every 4–6 months
Polynucleotides are commonly performed as:
A course of 2–4 treatments
Around 2–4 weeks apart
Maintenance depending on individual goals
Your practitioner will advise the most appropriate treatment plan during consultation.
The Bottom Line
Polynucloties vs Profhilo, If your main concern is hydration, glow, and improving overall skin quality, Profhilo is often an excellent choice.
If your goal is regeneration, strengthening the skin, improving elasticity, or addressing delicate areas such as under the eyes, Polynucleotides may be the better option.
The good news is that you don’t always have to choose one or the other. Modern aesthetics is moving away from simply filling and freezing and towards improving skin health, regeneration, and long-term ageing outcomes. Both Profhilo and Polynucleotides are part of this new generation of treatments that focus on healthier, stronger, more resilient skin.
If you’re unsure which treatment is right for you, booking a consultation allows us to assess your skin, discuss your concerns, and create a personalised treatment plan tailored to your goals.
For more information about advanced skin treatments, regenerative aesthetics, and personalised skincare solutions, visit Olivia Cole or You can read more in our previous blogs on treatments and skin advice Here
Which treatment is better for ageing skin?
This depends on your concerns. Profhilo is often chosen for skin laxity, dehydration, and dullness, while Polynucleotides may be more suitable for improving skin quality, fine lines, crepey skin, and overall regeneration.
Do Profhilo and Polynucleotides add volume?
No. Unlike dermal fillers, neither treatment is designed to create volume or alter facial contours. They work by improving the quality and condition of the skin itself.
Can Profhilo and Polynucleotides be combined?
Yes. The two treatments can complement each other. Profhilo can improve hydration and elasticity, while Polynucleotides focus on regeneration and skin repair. A personalised treatment plan can determine the best approach.
How many treatments will I need?
Most people achieve the best results with a course of treatments rather than a single session. Typically, Profhilo is performed as two treatments four weeks apart, while Polynucleotides are often recommended as a course of three sessions. Your practitioner will advise the most suitable plan for your skin having a consultation prior.
How long does it take to see results?
Results develop gradually as your skin responds to treatment. Profhilo usually begins improving hydration and skin texture within a few weeks, with optimal results seen after the second treatment. Polynucleotides work through tissue regeneration, so improvements often continue to develop over several weeks and months.
Is there any downtime after treatment?
Downtime is generally minimal for both treatments. You may experience some redness, swelling, or small injection marks immediately after treatment, but these typically settle within a few hours to a few days. Most people can return to their normal activities straight away.
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